Hepatitis B virus-induced CD4 lymphocytopenia: A rare cause of progressive multifocal leukoencephalopathy
Progressive multifocal leukoencephalopathy (PML) is a rare subacute-onset fatal demyelinating disease of the central nervous system caused by the John Cunningham (JC) virus.It usually occurs in impaired cell-mediated immunity settings such as Underarm Crutches lymphoproliferative disorders, chronic infective or granulomatous conditions on immunosup